Structure of PDB 3h0a Chain D

Receptor sequence
>3h0aD (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLN
DQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD
FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDN
LLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETD
MSLHPLLQEIYKDLY
3D structure
PDB3h0a Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
ChainD
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D T297 K301 Q314 V315 L318 P467 L468 E471 T85 K89 Q102 V103 L106 P255 L256 E259
BS02 D30 D L255 E259 R280 I281 G284 C285 R288 L330 L333 L340 I341 E343 L353 M364 L50 E54 R68 I69 G72 C73 R76 L118 L121 L128 I129 E131 L141 M152 MOAD: Ki=0.033uM
PDBbind-CN: -logKd/Ki=7.48,Ki=33nM
BindingDB: EC50=160nM,Ki=33nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3h0a, PDBe:3h0a, PDBj:3h0a
PDBsum3h0a
PubMed19464171
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

[Back to BioLiP]