Structure of PDB 3gxo Chain D

Receptor sequence
>3gxoD (length=339) Species: 1914 (Streptomyces lavendulae) [Search protein sequence]
GTAARAAAEETVNDILQGAWKARAIHVAVELGVPELLQEGPRTATALAEA
TGAHEQTLRRLLRLLATVGVFDDLGHDDLFAQNALSAVLLPDPASPVATD
ARFQAAPWHWRAWEQLTHSVRTGEASFDVANGTSFWQLTHEDPKARELFN
RAMGSVSLTEAGQVAAAYDFSGAATAVDIGGGRGSLMAAVLDAFPGLRGT
LLERPPVAEEARELLTGRGLADRCEILPGDFFETIPDGADVYLIKHVLHD
WDDDDVVRILRRIATAMKPDSRLLVIDNLIDERPAASTLFVDLLLLVLVG
GAERSESEFAALLEKSGLRVERSLPCGAGPVRIVEIRRA
3D structure
PDB3gxo Structural characterization of the mitomycin 7-O-methyltransferase.
ChainD
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H259 D260 D287 E313
Catalytic site (residue number reindexed from 1) H249 D250 D277 E303
Enzyme Commision number 2.1.1.316: mitomycin 6-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH D W146 M163 S167 G190 G192 E213 R214 D240 F241 K255 W136 M153 S157 G180 G182 E203 R204 D230 F231 K245
BS02 MQA D F113 F159 A162 M163 H256 H259 D260 N288 F103 F149 A152 M153 H246 H249 D250 N278
BS03 CA D E20 D24 E10 D14
BS04 CA D E134 D262 E124 D252
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:1901663 quinone biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3gxo, PDBe:3gxo, PDBj:3gxo
PDBsum3gxo
PubMed21538548
UniProtQ9X5T6|MMCR_STRLA Mitomycin biosynthesis 6-O-methyltransferase (Gene Name=mmcR)

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