Structure of PDB 3gqc Chain D

Receptor sequence

>3gqcD (length=433) Species: 9606 (Homo sapiens)

CNFISNFYSHSRLHHISMWKCELTEFVNTLQRQSNGIFPGREKLQSCIMH
VDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQ
NANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVPYDFH
AYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAV
RMEIKDQTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQ
LVTNLPGVGHSMESKLASLGIKTCGDLQYMTMAKLQKEFGPKTGQMLYRF
CRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLE
ATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNIARTVTLDQATDNAK
IIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPT

3D structure

• PDB: 3gqc Structure of the human Rev1-DNA-dNTP ternary complex.
• Chain: D
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	P725 K726	P331 K332
BS02	dna	D	I361 S568 E571 P650 G651 G653 S655 M656 R752 T783	I16 S174 E177 P256 G257 G259 S261 M262 R358 T389
BS03	dna	D	F352 Y353 H355 S356 R357 L358 H359 S362 S448 P456 S504 R505 A506 E507 K686 T687 R709 K710 S711 S713 A714 E715 N717 Y718 R742 K770 F771 G773 H774 G775	F7 Y8 H10 S11 R12 L13 H14 S17 S77 P85 S110 R111 A112 E113 K292 T293 R315 K316 S317 S319 A320 E321 N323 Y324 R348 K376 F377 G379 H380 G381
BS04	DCP	D	R357 M424 C426 F427 F428 A509 S510 Y513 R516 N522 D570 K625	R12 M53 C55 F56 F57 A115 S116 Y119 R122 N128 D176 K231
BS05	MG	D	D423 M424 D570	D52 M53 D176
BS06	MG	D	D570 E571	D176 E177
BS07	MG	D	T447 S448 E507 Y541	T76 S77 E113 Y147
BS08	MG	D	T647 L649 V652	T253 L255 V258

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:3gqc, PDBe:3gqc, PDBj:3gqc
• PDBsum: 3gqc
• PubMed: 19464298
• UniProt: Q9UBZ9|REV1_HUMAN DNA repair protein REV1 (Gene Name=REV1)