Structure of PDB 3gpo Chain D

Receptor sequence
>3gpoD (length=158) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATP
VGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGV
NSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKK
ISEAIQMR
3D structure
PDB3gpo The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
ChainD
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR D D10 I11 A22 N24 G30 D31 G32 V33 C34 L108 S110 T111 G112 V113 Y114 R144 D9 I10 A21 N23 G29 D30 G31 V32 C33 L107 S109 T110 G111 V112 Y113 R143 MOAD: Kd=5uM
External links
PDB RCSB:3gpo, PDBe:3gpo, PDBj:3gpo
PDBsum3gpo
PubMed19386706
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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