Structure of PDB 3gg2 Chain D

Receptor sequence

>3gg2D (length=427) Species: 837 (Porphyromonas gingivalis)

LDIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEQLNSGTIPIYEPG
LEKMIARNVKAGRLRFGTEIEQAVPEADIIFIAVGTPGSADMSYVLDAAR
SIGRAMSRYILIVTKSTVPVGSYRLIRKAIQEELDKREVLIDFDIASNPE
FLKEGNAIDDFMKPDRVVVGVDSDRARELITSLYKPMLLNNFRVLFMDIA
SAEMTKYAANAMLATRISFMNDVANLCERVGADVSMVRLGIGSDSRIGSK
FLYPGCGYGGSCFPKDVKALIRTAEDNGYRMEVLEAVERVNEKQKSILFD
KFSTYYKGNVQGRCVAIWGLSFKPGTDDMREAPSLVLIEKLLEVGCRVRV
YDPVAMKEAQKRLGDKVEYTTDMYDAVRGAEALFHVTEWKEFRMPDWSAL
SQAMAASLVIDGRNVYELPDFTLLNIG

3D structure

• PDB: 3gg2 Crystal structure of UDP-glucose 6-dehydrogenase from Porphyromonas gingivalis bound to product UDP-glucuronate
• Chain: D
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T199 E236 K288 N292 C344 D348
• Catalytic site (residue number reindexed from 1): T117 E154 K206 N210 C262 D266
• Enzyme Commision number: 1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UGA	D	F333 Y335 K405 E470	F251 Y253 K323 E388
BS02	UGA	D	F233 L234 K235 E236 K288 N292 I299 F333 Y335 Y340 G341 C344 F345 F404 K405	F151 L152 K153 E154 K206 N210 I217 F251 Y253 Y258 G259 C262 F263 F322 K323
BS03	UGA	D	M244 K245 L270 L271 N272 R275	M162 K163 L188 L189 N190 R193

Gene Ontology

Molecular Function

• GO:0003979 UDP-glucose 6-dehydrogenase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0051287 NAD binding

Biological Process

• GO:0000271 polysaccharide biosynthetic process

External links

• PDB: RCSB:3gg2, PDBe:3gg2, PDBj:3gg2
• PDBsum: 3gg2
• UniProt: Q7MVC7