Structure of PDB 3gd7 Chain D

Receptor sequence
>3gd7D (length=375) Species: 9606,83333 [Search protein sequence]
DIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKS
TLLSAFLRLLNTEGEIQIDGVSWDSITLEQWRKAFGVIPQKVFIFSGTFR
KNLDPNAAHSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHK
QLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCE
ARIEAMLECDQFLVIEENKVRQYDSILELYHYPADRFVAGFIGSPKMNFL
PVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLP
SDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVEEGATFAI
GLPPERCHLFREDGTACRRLHKEPG
3D structure
PDB3gd7 Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
7.5.2.1: ABC-type maltose transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B44 D F1294 F1296 S1297 K1302 F93 F95 S96 K101
BS02 B44 D Y1219 I1226 G1247 S1248 G1249 K1250 S1251 T1252 L1260 Y18 I25 G46 S47 G48 K49 S50 T51 L59
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0043190 ATP-binding cassette (ABC) transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3gd7, PDBe:3gd7, PDBj:3gd7
PDBsum3gd7
PubMed
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR);
P68187|MALK_ECOLI Maltose/maltodextrin import ATP-binding protein MalK (Gene Name=malK)

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