Structure of PDB 3g93 Chain D

Receptor sequence
>3g93D (length=440) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
GKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVV
LCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRF
SLATMSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFG
KRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIY
RNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDHQNLILTVLS
LFFAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRA
KMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSS
ALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIART
ELFLFFTTILQNFSIASPVPPEDIDLTPVPPSYQIRFLAR
3D structure
PDB3g93 Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
ChainD
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T302 F429 C436
Catalytic site (residue number reindexed from 1) T258 F385 C392
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D R98 F296 G299 T300 T302 T303 Q357 I363 V367 H369 P428 F429 S430 R434 C436 L437 G438 R71 F252 G255 T256 T258 T259 Q313 I319 V323 H325 P384 F385 S386 R390 C392 L393 G394
BS02 PB2 D A298 G299 T302 I363 A254 G255 T258 I319
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008392 arachidonate epoxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0019373 epoxygenase P450 pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3g93, PDBe:3g93, PDBj:3g93
PDBsum3g93
PubMed19397311
UniProtP00178|CP2B4_RABIT Cytochrome P450 2B4 (Gene Name=CYP2B4)

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