Structure of PDB 3g4g Chain D

Receptor sequence
>3g4gD (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
NQVSEFISNTFLDEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTI
FQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL
LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYND
SSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSK
HMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKP
LQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDY
IVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ
3D structure
PDB3g4g Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H330 H366 D367 D484 H89 H125 D126 D243
BS02 CA D H271 R274 H30 R33
BS03 D71 D F196 H326 N487 T499 I502 F506 S534 Q535 F538 F6 H85 N246 T258 I261 F265 S293 Q294 F297 MOAD: ic50=19nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3g4g, PDBe:3g4g, PDBj:3g4g
PDBsum3g4g
PubMed20037581
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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