Structure of PDB 3g4c Chain D

Receptor sequence
>3g4cD (length=211) Species: 2336 (Thermotoga maritima) [Search protein sequence]
MKIDILDKGFVELVDVMGNDLSAVRAARVSFERDRHLIEYLMKHGHETPF
EHIVFTFHVKAPIFVARQWFRHRIASYNELCGRYSKLSYEFYIPSPERLE
GYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTR
FFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLK
YAYKGDILKEV
3D structure
PDB3g4c An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
ChainD
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP D Q75 R78 R174 Q68 R71 R167
BS02 FAD D N85 E86 C88 N78 E79 C81
BS03 FAD D T55 E58 I81 N163 R165 T48 E51 I74 N156 R158
BS04 FAD D R78 H79 R80 I81 N169 L173 R174 H178 R71 H72 R73 I74 N162 L166 R167 H171
BS05 UMP D E86 C88 G89 R90 R147 E79 C81 G82 R83 R140
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3g4c, PDBe:3g4c, PDBj:3g4c
PDBsum3g4c
PubMed19370033
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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