Structure of PDB 3fpa Chain D

Receptor sequence
>3fpaD (length=225) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDL
AEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDR
PGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTK
LTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGA
ASLDAGDFAAMSAAAFDRNWVAGLV
3D structure
PDB3fpa Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase.
ChainD
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) T11 G12 K15 T16 K37 T41 G54 E108
Catalytic site (residue number reindexed from 1) T11 G12 K15 T16 K37 T41 G54 E108
Enzyme Commision number 6.3.3.3: dethiobiotin synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTB D T11 T41 R45 A73 T11 T41 R45 A73
BS02 MG D T16 D49 E108 T16 D49 E108
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004141 dethiobiotin synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009102 biotin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3fpa, PDBe:3fpa, PDBj:3fpa
PDBsum3fpa
PubMed20565114
UniProtP9WPQ5|BIOD_MYCTU Dethiobiotin synthetase BioD (Gene Name=bioD)

[Back to BioLiP]