Structure of PDB 3ffk Chain D

Receptor sequence
>3ffkD (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
VEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQL
RNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFE
SATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEV
PVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERS
GRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKV
SNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTE
ERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP
3D structure
PDB3ffk Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D G186 D187 E209 D259 G160 D161 E183 D233
BS02 CA D G65 D66 E97 V145 G39 D40 E71 V119
BS03 CA D D109 G114 A116 D83 G88 A90
BS04 CA D E302 D303 E327 E276 D277 E301
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:3ffk, PDBe:3ffk, PDBj:3ffk
PDBsum3ffk
PubMed19666512
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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