Structure of PDB 3ff6 Chain D

Receptor sequence
>3ff6D (length=733) Species: 9606 (Homo sapiens) [Search protein sequence]
VTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPKDILTYT
ELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDIT
FRIGSFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFH
VAWVDPEDPHKGFKYLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDI
IGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIGAYLVRLG
QRVIQVENSHIILTGASALNKVLGREVYTSNNQLGGVQIMHYNGVSHITV
PDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSRAPYDPR
WMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGV
IAVETRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNR
EKLPLMIFANWRGFSGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPY
AELRGGSWVVIDATINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLIK
SMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQ
FADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQVKQEILQA
SGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQARSTIR
ENITYLKHDSVLKTIRGLVEENPEVAVDCVIYL
3D structure
PDB3ff6 The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
ChainD
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RCP D A1964 L1965 V1968 A268 L269 V272 BindingDB: IC50=38nM
BS02 RCP D V2128 G2159 F2160 S2161 L2229 E2230 E2232 G2233 E2236 V432 G463 F464 S465 L533 E534 E536 G537 E540 BindingDB: IC50=38nM
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:3ff6, PDBe:3ff6, PDBj:3ff6
PDBsum3ff6
PubMed19390150
UniProtO00763|ACACB_HUMAN Acetyl-CoA carboxylase 2 (Gene Name=ACACB)

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