Structure of PDB 3fc6 Chain D

Receptor sequence
>3fc6D (length=241) Species: 10090 (Mus musculus) [Search protein sequence]
QLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRF
AHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSR
RYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDA
EFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMF
PRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB3fc6 Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
ChainD
Resolution2.063 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LX2 D N223 F255 L258 S262 I293 M296 L297 T300 R303 I311 F313 L314 F324 F333 I337 F338 H419 W441 N21 F53 L56 S60 I91 M94 L95 T98 R101 I109 F111 L112 F122 F131 I135 F136 H217 W239
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3fc6, PDBe:3fc6, PDBj:3fc6
PDBsum3fc6
PubMed19167885
UniProtQ9Z0Y9|NR1H3_MOUSE Oxysterols receptor LXR-alpha (Gene Name=Nr1h3)

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