Structure of PDB 3cs9 Chain D

Receptor sequence
>3cs9D (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
DKWEMERTDITMKHKLGGGQYGEVYEGVWTVAVKTLKEDTMEVEEFLKEA
AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNA
VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRL
MTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM
SPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFA
EIHQAFETMFQES
3D structure
PDB3cs9 Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
ChainD
Resolution2.21 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D126 A128 R130 N131 D144 P165
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NIL D L248 Y253 A269 K271 E286 V289 M290 T315 F317 M318 H361 A380 D381 F382 L16 Y21 A32 K34 E49 V52 M53 T78 F80 M81 H124 A143 D144 F145 MOAD: ic50<33uM
BindingDB: Kd=10nM,IC50=20nM,Ki=1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3cs9, PDBe:3cs9, PDBj:3cs9
PDBsum3cs9
PubMed15710326
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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