Structure of PDB 3cos Chain D

Receptor sequence
>3cosD (length=381) Species: 9606 (Homo sapiens) [Search protein sequence]
SMGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHT
DATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLC
RKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGT
STFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGS
TCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNP
RDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIG
VAAGSKGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLD
ALVTHTLPFDKISEAFDLMNQGKSIRTILIF
3D structure
PDB3cos Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn.
ChainD
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C47 H48 T49 T52 H69 E70 C99 C102 C105 C113 S117 C180 T184 R375
Catalytic site (residue number reindexed from 1) C48 H49 T50 T53 H70 E71 C100 C103 C106 C114 S118 C181 T185 R376
Enzyme Commision number 1.1.1.105: all-trans-retinol dehydrogenase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C47 H69 C180 C48 H70 C181
BS02 ZN D C99 C102 C105 C113 C100 C103 C106 C114
BS03 NAD D H48 T49 C180 T184 G205 V209 D229 I230 C274 A275 T280 I298 G299 V300 R375 H49 T50 C181 T185 G206 V210 D230 I231 C275 A276 T281 I299 G300 V301 R376
Gene Ontology
Molecular Function
GO:0003960 NADPH:quinone reductase activity
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0004032 aldose reductase (NADPH) activity
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0005503 all-trans retinal binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0018479 benzaldehyde dehydrogenase (NAD+) activity
GO:0019841 retinol binding
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0006066 alcohol metabolic process
GO:0006067 ethanol metabolic process
GO:0006081 cellular aldehyde metabolic process
GO:0006629 lipid metabolic process
GO:0010430 fatty acid omega-oxidation
GO:0042572 retinol metabolic process
GO:0046164 alcohol catabolic process
GO:0046294 formaldehyde catabolic process
GO:1901661 quinone metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3cos, PDBe:3cos, PDBj:3cos
PDBsum3cos
PubMed
UniProtP08319|ADH4_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH4 (Gene Name=ADH4)

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