Structure of PDB 3cm7 Chain D

Receptor sequence
>3cm7D (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHC
GGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLV
3D structure
PDB3cm7 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C300 C303 H320 C327 C47 C50 H67 C74
BS02 X22 D E337 N340 H343 L344 S347 E84 N87 H90 L91 S94 BindingDB: IC50=290nM
BS03 X22 D K299 G306 L307 T308 D309 W310 E314 Q319 W323 K46 G53 L54 T55 D56 W57 E61 Q66 W70 BindingDB: IC50=290nM
BS04 X22 D R258 C303 G304 G305 K322 W323 Y324 P325 R5 C50 G51 G52 K69 W70 Y71 P72 BindingDB: IC50=290nM
External links
PDB RCSB:3cm7, PDBe:3cm7, PDBj:3cm7
PDBsum3cm7
PubMed18851976
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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