Structure of PDB 3cm2 Chain D

Receptor sequence
>3cm2D (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHC
GGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLV
RT
3D structure
PDB3cm2 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C300 C303 H320 C327 C47 C50 H67 C74
BS02 X23 D L292 K297 V298 G306 L307 T308 D309 W310 E314 Q319 L39 K44 V45 G53 L54 T55 D56 W57 E61 Q66 MOAD: Ki=340nM
PDBbind-CN: -logKd/Ki=6.47,Ki=340nM
BindingDB: IC50=110nM
External links
PDB RCSB:3cm2, PDBe:3cm2, PDBj:3cm2
PDBsum3cm2
PubMed18851976
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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