Structure of PDB 3cke Chain D

Receptor sequence
>3ckeD (length=284) Species: 33178 (Aspergillus terreus) [Search protein sequence]
SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWKARKKVAAGFSRVTCLYF
PKALDDRIHFACRLLTVLFLIDDLLEFEEGSAYNEKLIPISRGDVLPDRS
IPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRRPMGLGGYL
EYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIY
SYEKELYLCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSA
EGLETPGLAAYVEGLEYQMSGNELWSQTTLRYSV
3D structure
PDB3cke X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis.
ChainD
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y67 F87 F153 K181 W308
Catalytic site (residue number reindexed from 1) Y49 F69 F132 K159 W275
Enzyme Commision number 4.2.3.9: aristolochene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D N219 S223 E227 N197 S201 E205
BS02 POP D N219 E227 Y315 N197 E205 Y282
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0045483 aristolochene synthase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3cke, PDBe:3cke, PDBj:3cke
PDBsum3cke
PubMed18385128
UniProtQ9UR08|ARIS_ASPTE Aristolochene synthase (Gene Name=Ari1)

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