Structure of PDB 3c6m Chain D

Receptor sequence
>3c6mD (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
SRHSTLDFMLLRIYPHGLVLLDLQSRVKRLPPIVRGGAIDRYWPTADGRL
VEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAI
MGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKK
YMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVP
ISTSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLY
CPVEFSKEIVCVPSYLELWVFYTVWKKA
3D structure
PDB3c6m Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
ChainD
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.22: spermine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SPM D Y134 D167 V168 N169 Y177 D201 D276 Y351 E353 W355 Y53 D86 V87 N88 Y96 D120 D195 Y265 E267 W269
BS02 MTA D L164 N169 G198 G199 D201 E220 I221 V225 C256 D276 L277 T278 I282 L83 N88 G117 G118 D120 E139 I140 V144 C175 D195 L196 T197 I201 MOAD: Ki=0.3uM
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016768 spermine synthase activity
Biological Process
GO:0006555 methionine metabolic process
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0006597 spermine biosynthetic process
GO:0008215 spermine metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c6m, PDBe:3c6m, PDBj:3c6m
PDBsum3c6m
PubMed18367445
UniProtP52788|SPSY_HUMAN Spermine synthase (Gene Name=SMS)

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