Structure of PDB 3b78 Chain D

Receptor sequence
>3b78D (length=207) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
AFLGDGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQ
SIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIRNGAL
LRVYVPRSSLPGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEE
GGHLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALP
DYASQPG
3D structure
PDB3b78 The nature and character of the transition state for the ADP-ribosyltransferase reaction.
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E553
Catalytic site (residue number reindexed from 1) E155
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D H440 G441 T442 A446 S449 I450 R456 R458 Y470 I471 A478 Y481 E546 E553 H42 G43 T44 A48 S51 I52 R58 R60 Y72 I73 A80 Y83 E148 E155
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3b78, PDBe:3b78, PDBj:3b78
PDBsum3b78
PubMed18583986
UniProtP11439|TOXA_PSEAE Exotoxin A (Gene Name=eta)

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