Structure of PDB 3b60 Chain D

Receptor sequence
>3b60D (length=572) [Search protein sequence]
WQTFRRLWPTIAPFKAGLIVAGIALILNAASDTFMLSLLKPLLDDGFGKT
DRSVLLWMPLVVIGLMILRGITSYISSYCISWVSGKVVMTMRRRLFGHMM
GMPVAFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIM
MFYYSWQLSIILVVLAPIVSIAIRVVSKRFRSISKNMQNTMGQVTTSAEQ
MLKGHKEVLIFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIA
SLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQ
RGMAACQTLFAILDSEQEKDEGKRVIDRATGDLEFRNVTFTYPGREVPAL
RNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGHILMDGHDLRE
YTLASLRNQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYA
MDFINKMDNGLDTIIGENGVLLSGGQRQRIAIARALLRDSPILILDEATS
ALDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGIIVER
GTHSELLAQHGVYAQLHKMQFG
3D structure
PDB3b60 Flexibility in the ABC transporter MsbA: Alternating access with a twist.
ChainD
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.5.2.6: ABC-type lipid A-core oligosaccharide transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP D L480 S482 L471 S473
BS02 ANP D Y351 S378 G379 S380 G381 K382 S383 T384 Y342 S369 G370 S371 G372 K373 S374 T375
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0034040 ATPase-coupled lipid transmembrane transporter activity
GO:0042802 identical protein binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3b60, PDBe:3b60, PDBj:3b60
PDBsum3b60
PubMed18024585
UniProtP63359|MSBA_SALTY ATP-dependent lipid A-core flippase (Gene Name=msbA)

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