Structure of PDB 3b2z Chain D

Receptor sequence
>3b2zD (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLV
VTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQD
LCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNML
HDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY
GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAAL
WCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCL
3D structure
PDB3b2z Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.82: ADAMTS-4 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D D328 H361 H365 H371 D108 H141 H145 H151
BS02 CA D E221 D304 D311 C423 D426 E6 D84 D91 C203 D206
BS03 CA D E221 D304 D426 E6 D84 D206
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3b2z, PDBe:3b2z, PDBj:3b2z
PDBsum3b2z
PubMed18042673
UniProtO75173|ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (Gene Name=ADAMTS4)

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