Structure of PDB 3azb Chain D

Receptor sequence
>3azbD (length=140) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
DTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGH
FPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPV
LPGDTLTMQANLISFKIAKLSGVGYVNGKVVINISEMTFA
3D structure
PDB3azb Structural basis for the functional and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum
ChainD
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H133 I139 G142 V143 E147
Catalytic site (residue number reindexed from 1) H50 I56 G59 V60 E64
Enzyme Commision number 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KM1 D L96 P97 H98 A150 Q151 G154 N167 F169 L170 F171 F226 L13 P14 H15 A67 Q68 G71 N84 F86 L87 F88 F139 PDBbind-CN: -logKd/Ki=4.92,IC50=12uM
Gene Ontology
Molecular Function
GO:0016836 hydro-lyase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3azb, PDBe:3azb, PDBj:3azb
PDBsum3azb
PubMed21843645
UniProtQ965D7

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