Structure of PDB 3az9 Chain D

Receptor sequence
>3az9D (length=144) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
DTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGH
FPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPV
LPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFA
3D structure
PDB3az9 Structural basis for the functional and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum
ChainD
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H133 I139 G142 V143 E147
Catalytic site (residue number reindexed from 1) H50 I56 G59 V60 E64
Enzyme Commision number 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K91 D H133 P141 G142 V143 H50 P58 G59 V60 PDBbind-CN: -logKd/Ki=6.00,Kd~1uM
BS02 K91 D H98 E147 A150 Q151 F169 L170 F171 H15 E64 A67 Q68 F86 L87 F88 PDBbind-CN: -logKd/Ki=6.00,Kd~1uM
Gene Ontology
Molecular Function
GO:0016836 hydro-lyase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3az9, PDBe:3az9, PDBj:3az9
PDBsum3az9
PubMed21843645
UniProtQ965D7

[Back to BioLiP]