Structure of PDB 3al5 Chain D

Receptor sequence
>3al5D (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
QHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVG
GKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDE
KYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSP
GLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNP
DLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHL
PSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVL
HIQDKAYS
3D structure
PDB3al5 Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
ChainD
Resolution2.503 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.42: tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D H160 H235 H157 H232
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0102524 tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity
Biological Process
GO:0008033 tRNA processing
GO:0031591 wybutosine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3al5, PDBe:3al5, PDBj:3al5
PDBsum3al5
PubMed20972222
UniProtA2RUC4|TYW5_HUMAN tRNA wybutosine-synthesizing protein 5 (Gene Name=TYW5)

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