Structure of PDB 3a4k Chain D

Receptor sequence

>3a4kD (length=298) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence]

KSALEKLLSLIENLTNQEFKQATNSLISFIYKLNRNEVIELVRSIGILPE
AIKPSSTQEKLFSKAGDIVLAKAFQLLNLNSKPLEQRGNAGDVIALSKEF
NYGLVADAKSFRLSRTAKNQKDFKVKALSEWREDKDYAVLTAPFFQYPTT
KSQIFKQSLDENVLLFSWEHLAILLQLDLEETNIFSFEQLWNFPKKQSKK
TSVSDAENNFMRDFNKYFMDLFKIDKDTLNQLLQKEINFIEERSLIEKEY
WKKQINIIKNFTREEAIEALLKDINMSSKIETIDSFIKGIKSNDRLYL

3D structure

PDB

3a4k Structures of restriction endonuclease HindIII in complex with its cognate DNA and divalent cations

Chain

Resolution

2.17 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.21.4: type II site-specific deoxyribonuclease.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	A118 N120 P149 T150 T151 K152 S153 Q154	A117 N119 P148 T149 T150 K151 S152 Q153
BS02	dna	D	F20 K21 S56 T58 K61 R88 K122	F19 K20 S55 T57 K60 R87 K121
BS03	dna	D	R88 G89 N90 K125 W132	R87 G88 N89 K124 W131
BS04	dna	D	L49 E60 S64 K110 S111 F112 R113 R116 T117 A118 D123 K125	L48 E59 S63 K109 S110 F111 R112 R115 T116 A117 D122 K124
BS05	MN	D	D93 D108 A109	D92 D107 A108

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity
GO:0009036	type II site-specific deoxyribonuclease activity

	Biological Process
GO:0009307	DNA restriction-modification system

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Molecular Function

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Biological Process

External links

PDB	RCSB:3a4k, PDBe:3a4k, PDBj:3a4k
PDBsum	3a4k
PubMed	19966419
UniProt	P43870\|T2D3_HAEIN Type II restriction enzyme HindIII (Gene Name=hindIIIR)

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