Structure of PDB 2zzb Chain D

Receptor sequence

>2zzbD (length=484) Species: 9606 (Homo sapiens)

SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTC
VNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHI
GSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLI
ATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFL
AGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQI
EAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKI
NEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYA
GSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPL
EWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCG
LTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASIL

3D structure

• PDB: 2zzb Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1.
• Chain: D
• Resolution: 3.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): L55 C59 C64 K67 Y200 E204 G470 H472 E477
• Catalytic site (residue number reindexed from 1): L46 C50 C55 K58 Y191 E195 G461 H463 E468
• Enzyme Commision number: 1.11.1.2: NADPH peroxidase.
  1.8.1.9: thioredoxin-disulfide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	D	I18 G19 G21 S22 L41 D42 F43 T58 G63 C64 K67 Y131 G132 A160 T161 Y200 G333 D334 E341 L342 T343	I9 G10 G12 S13 L32 D33 F34 T49 G54 C55 K58 Y122 G123 A151 T152 Y191 G324 D325 E332 L333 T334
BS02	TPT	D	N107 S111 W114	N98 S102 W105

Gene Ontology

Molecular Function

• GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
• GO:0016491 oxidoreductase activity
• GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0045454 cell redox homeostasis

External links

• PDB: RCSB:2zzb, PDBe:2zzb, PDBj:2zzb
• PDBsum: 2zzb
• PubMed: 19525010
• UniProt: Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic (Gene Name=TXNRD1)