Structure of PDB 2ztu Chain D

Receptor sequence
>2ztuD (length=241) Species: 296 (Pseudomonas fragi) [Search protein sequence]
MLKGKVAVVTGSTSGIGLGIATALAAQGADIVLNGFGDAAEIEKVRAGLA
AQHGVKVLYDGADLSKGEAVRGLVDNAVRQMGRIDILVNNAGIQHTALIE
DFPTEKWDAILALNLSAVFHGTAAALPHMKKQGFGRIINIASAHGLVASA
NKSAYVAAKHGVVGFTKVTALETAGQGITANAICPGWVRETAARELLSEK
QPSLQFVTPEQLGGTAVFLASDAAAQITGTTVSVDGGWTAR
3D structure
PDB2ztu Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor.
ChainD
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G15 N114 S142 Y155 K159
Catalytic site (residue number reindexed from 1) G15 N114 S142 Y155 K159
Enzyme Commision number 1.1.1.30: 3-hydroxybutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D G11 T13 S14 G15 I16 N34 G35 F36 D63 L64 N90 S142 Y155 K159 P185 G186 W187 V188 G11 T13 S14 G15 I16 N34 G35 F36 D63 L64 N90 S142 Y155 K159 P185 G186 W187 V188
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2ztu, PDBe:2ztu, PDBj:2ztu
PDBsum2ztu
PubMed19122202
UniProtQ5KST5

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