Structure of PDB 2ztl Chain D

Receptor sequence
>2ztlD (length=260) Species: 296 (Pseudomonas fragi) [Search protein sequence]
MLKGKVAVVTGSTSGIGLGIATALAAQGADIVLNGFGDAAEIEKVRAGLA
AQHGVKVLYDGADLSKGEAVRGLVDNAVRQMGRIDILVNNAGIQHTALIE
DFPTEKWDAILALNLSAVFHGTAAALPHMKKQGFGRIINIASAHGLVASA
NKSAYVAAKHGVVGFTKVTALETAGQGITANAICPGWVRTPLVEKQISAL
AEKNGVDQETAARELLSEKQPSLQFVTPEQLGGTAVFLASDAAAQITGTT
VSVDGGWTAR
3D structure
PDB2ztl Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor.
ChainD
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G15 N114 S142 Y155 K159 L200
Catalytic site (residue number reindexed from 1) G15 N114 S142 Y155 K159 L200
Enzyme Commision number 1.1.1.30: 3-hydroxybutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D G11 T13 S14 I16 F36 L64 N90 G92 L113 Y155 K159 P185 G186 W187 V188 T190 V193 G11 T13 S14 I16 F36 L64 N90 G92 L113 Y155 K159 P185 G186 W187 V188 T190 V193
BS02 3HL D Q94 S142 H144 K152 Y155 W187 Q196 Q94 S142 H144 K152 Y155 W187 Q196
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2ztl, PDBe:2ztl, PDBj:2ztl
PDBsum2ztl
PubMed19122202
UniProtQ5KST5

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