Structure of PDB 2yic Chain D

Receptor sequence
>2yicD (length=809) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
NARVIELIAAYRNRGHLMADIDPLRLDNTRFWDLDREFKKLRDILSVLRD
AYCRHVGVEYTHILEPEQQRWIQERVETKHDKPTVAEQKYILSKLNAAEA
FETFLQTKYVGQKRFSLEGAETVIPMMDAVIDQCAEHGLDEVVIAMPHRG
RLNVLANIVGKPYSQIFSEFGDVKYHLGATGTYIQMFGDNDIEVSLTANP
SHLEAVDPVLEGLVRAKQDLLDTGEEGSDNRFSVVPLMLHGDAAFAGQGV
VAETLNLALLRGYRTGGTIHIVVNNQIGFTTAPTDSRSSEYCTDVAKMIG
APIFHVNGDDPEACAWVARLAVDFRQAFKKDVVIDMLCYRRRGHNEGDDP
SMTQPYMYDVIDTKRGSRKAYTEALIGRGDISMKEAEDALRDYQGQLERV
FNEVRELEKHEILATAVDKAMLQRIGDAHLALPEGFTVHPRVRPVLEKRR
EMAYEGRIDWAFAELLALGSLIAEGKLVRLSGQDTQRGTFTQRHAVIVDR
KTGEEFTPLQLLATNPDGTPTGGKFLVYNSALSEFAAVGFEYGYSVGNPD
AMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGP
DHTSGRIERFLQLWAEGSMTIAMPSTPANYFHLLRRHGKDGIQRPLIVFT
PKSMLRNKAAVSDIRDFTESKFRSVLEEPMYTDGEGDRNKVTRLLLTSGK
IYYELAARKAKENREDVAIVRIEQLAPLPRRRLAETLDRYPNVKEKFWVQ
EEPANQGAWPSFGLTLPEILPDHFTGLKRISRRAMSAPSSGSSKVHAVEQ
QEILDTAFG
3D structure
PDB2yic Functional Plasticity and Allosteric Regulation of Alpha-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism.
ChainD
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring).
2.2.1.5: 2-hydroxy-3-oxoadipate synthase.
2.3.1.61: dihydrolipoyllysine-residue succinyltransferase.
4.1.1.71: 2-oxoglutarate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP D Q901 L950 E952 Q976 F980 Q483 L532 E534 Q558 F562
BS02 TPP D R540 S604 L606 G644 D645 A646 A647 N678 I680 G681 H747 R149 S201 L203 G241 D242 A243 A244 N275 I277 G278 H344
BS03 MG D D645 N678 I680 D242 N275 I277
BS04 CA D D1004 H1055 D1058 I1060 D586 H637 D640 I642
Gene Ontology
Molecular Function
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:2yic, PDBe:2yic, PDBj:2yic
PDBsum2yic
PubMed21867916
UniProtA0R2B1|KGD_MYCS2 Multifunctional 2-oxoglutarate metabolism enzyme (Gene Name=kgd)

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