Structure of PDB 2y3i Chain D

Receptor sequence
>2y3iD (length=414) Species: 9606 (Homo sapiens) [Search protein sequence]
MSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLD
NGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGP
EVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRA
SLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALE
SPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNME
IGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQAT
VASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGT
KALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLEL
LEGKVLPGVDALSN
3D structure
PDB2y3i Interaction of Human 3-Phosphoglycerate Kinase with its Two Substrates: Is Substrate Antagonism a Kinetic Advantage?
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.2.3: phosphoglycerate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LA8 D G213 A214 K215 N336 P338 G340 E343 G372 G373 D374 T375 G212 A213 K214 N335 P337 G339 E342 G371 G372 D373 T374
BS02 ALF D K215 G395 G396 K214 G394 G395
Gene Ontology
Molecular Function
GO:0004618 phosphoglycerate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0043531 ADP binding
GO:0047134 protein-disulfide reductase (NAD(P)H) activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0016525 negative regulation of angiogenesis
GO:0030855 epithelial cell differentiation
GO:0031639 plasminogen activation
GO:0061621 canonical glycolysis
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0045121 membrane raft
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2y3i, PDBe:2y3i, PDBj:2y3i
PDBsum2y3i
PubMed21549713
UniProtP00558|PGK1_HUMAN Phosphoglycerate kinase 1 (Gene Name=PGK1)

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