Structure of PDB 2xu1 Chain D

Receptor sequence
>2xu1D (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDAGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFNNKYWLVKNSWGEEWGMGGYVKMAKDRR
NHCGIASAASYPTV
3D structure
PDB2xu1 Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions.
ChainD
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 C25 H163 N181
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 424 D G23 C25 E63 G67 G68 L69 M70 A135 M161 D162 H163 G23 C25 E63 G67 G68 L69 M70 A135 M161 D162 H163
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2xu1, PDBe:2xu1, PDBj:2xu1
PDBsum2xu1
PubMed21184410
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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