Structure of PDB 2x9n Chain D

Receptor sequence
>2x9nD (length=247) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
APAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKER
SNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPL
VKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCMAF
SLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKW
RRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA
3D structure
PDB2x9n High-Resolution Structures of Trypanosoma Brucei Pteridine Reductase Ligand Complexes Inform on the Placement of New Molecular Entities in the Active Site of a Potential Drug Target
ChainD
Resolution1.15 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R14 D161 Y174 K178
Catalytic site (residue number reindexed from 1) R12 D140 Y153 K157
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D R14 I15 H33 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T126 L159 K178 P204 G205 S207 R12 I13 H31 Y32 H33 N34 S35 D60 L61 N91 A92 S93 T114 L138 K157 P183 G184 S186
BS02 AX3 D R14 S95 F97 Y174 P210 R12 S93 F95 Y153 P189 MOAD: Ki>0.035mM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity

View graph for
Molecular Function
External links
PDB RCSB:2x9n, PDBe:2x9n, PDBj:2x9n
PDBsum2x9n
PubMed21123874
UniProtO76290

[Back to BioLiP]