Structure of PDB 2x2f Chain D

Receptor sequence
>2x2fD (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
EFSMEDLIPLVNRLQDAFSADLDLPQIAVVGGQSAGKSSVLENFVGRDFL
PRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDR
VTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIR
DMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKL
DLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERK
FFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSI
EKEVEEYKNFSRVDEMLRMYHALKEALSIIGNI
3D structure
PDB2x2f G Domain Dimerization Controls Dynamin'S Assembly-Stimulated Gtpase Activity.
ChainD
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP D S41 G43 K44 S45 S46 R59 G60 K206 D208 L209 V235 N236 R237 S238 Q239 S34 G36 K37 S38 S39 R52 G53 K199 D201 L202 V228 N229 R230 S231 Q232
BS02 ALF D Q40 S41 K44 V64 T65 G139 Q33 S34 K37 V57 T58 G132
BS03 MG D S45 T65 S38 T58
BS04 NA D S41 G60 S61 G62 V64 S34 G53 S54 G55 V57
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2x2f, PDBe:2x2f, PDBj:2x2f
PDBsum2x2f
PubMed20428113
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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