Structure of PDB 2x2e Chain D

Receptor sequence
>2x2eD (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRD
FLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAET
DRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQ
IRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVIT
KLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAE
RKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLL
SIEKEVEEYKNFRPDKHGTDSRVDEMLRMYHALKEALSIIG
3D structure
PDB2x2e G Domain Dimerization Controls Dynamin'S Assembly-Stimulated Gtpase Activity.
ChainD
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 GDP D S41 G43 K44 S45 S46 R59 G60 K206 D208 L209 N236 R237 S238 Q239 S36 G38 K39 S40 S41 R54 G55 K201 D203 L204 N231 R232 S233 Q234
BS02 ALF D Q40 S41 K44 V64 T65 G139 Q35 S36 K39 V59 T60 G134
BS03 MG D S45 T65 S40 T60
BS04 NA D S41 G60 S61 G62 V64 S36 G55 S56 G57 V59
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2x2e, PDBe:2x2e, PDBj:2x2e
PDBsum2x2e
PubMed20428113
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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