Structure of PDB 2wyw Chain D

Receptor sequence

>2wywD (length=258) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MLTVDLSGKKALVMGVTNQRSLGFAIAAKLKEAGAEVALSYQAERLRPEA
EKLAEALGGALLFRADVTQDEELDALFAGVKEAFGGLDYLVHAIAFAPRE
AMEGRYIDTRRQDWLLALEVSAYSLVAVARRAEPLLREGGGIVTLTYYAS
EKVVPKYNVMAIAKAALEASVRYLAYELGPKGVRVNAISAGPVRTVAARS
IPGFTKMYDRVAQTAPLRRNITQEEVGNLGLFLLSPLASGITGEVVYVDA
GYHIMGME

3D structure

PDB

2wyw High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and in complex with NAD+ and triclosan.

Chain

Resolution

1.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S21 Y147 Y157 M160 K164
Catalytic site (residue number reindexed from 1)	S21 Y147 Y157 M160 K164
Enzyme Commision number	1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	D	G15 V16 T17 S21 L22 Q42 D66 V67 A93 I94 A95 V120 L145 T146 K164 A190 P192 V193 T195 A197	G15 V16 T17 S21 L22 Q42 D66 V67 A93 I94 A95 V120 L145 T146 K164 A190 P192 V193 T195 A197
BS02	TCL	D	A95 A97 Y147 Y157 A197 A198 S200 I201	A95 A97 Y147 Y157 A197 A198 S200 I201

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004318	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491	oxidoreductase activity

	Biological Process
GO:0006633	fatty acid biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2wyw, PDBe:2wyw, PDBj:2wyw
PDBsum	2wyw
PubMed	23027736
UniProt	Q5SLI9

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