Structure of PDB 2wyo Chain D

Receptor sequence
>2wyoD (length=492) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
GHMVLKLLLELGAERYAEQFAAKCHELGMVMKESAGPGRVPVPVTLQPSM
ISRGEFGTLCCMQPLWNEAVDNTARNFTFLRDALQETAASDVNFTGKLLN
MLQEVYLSGGPFQQLMLGIFRTDYMREGVSTTASRWKNVEINTISCSFAG
LSPLITEFHQHIAAYLQVLQKARGKSWIWGKGNCRLERSVSGDVVPKAIA
DAVRAWVEQQKFASLRASWEQFQLGVLDTAPVVLVVVQENERNTADQYAL
LMRVLEEHRIRFIFRTLQELHLSLKLHSISPEQPPLAVVDGHYPIAVAYF
RSTYVPEDFPTDATWAARLSLERSSAIKCPSIPYHLLTFKKLQQLLCDVD
RVLVPVAFCGDSDKAGLLQRHFVPQYSLNPKEVGEEAVEKVIHDVLQRPD
QYVVMSRIQFHVSTGSLLARGDVVQLERNMCSEVGIFGVILSAAKGSSVG
TNGSSVLFNTFAGYTVRSKPADADDGGVMAGVAALDSLAVVP
3D structure
PDB2wyo Structure of Trypanosoma Brucei Glutathione Synthetase; Domain and Loop Alterations in the Catalytic Cycle of a Highly Conserved Enzyme.
ChainD
Resolution3.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R119 E143 N145 S150 K363 R530
Catalytic site (residue number reindexed from 1) R121 E140 N142 S147 K340 R467
Enzyme Commision number 6.3.2.3: glutathione synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH D R119 S148 S150 F151 E264 N266 R324 Y327 R530 G540 V541 M542 R121 S145 S147 F148 E241 N243 R301 Y304 R467 G477 V478 M479
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004363 glutathione synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0043295 glutathione binding
GO:0046872 metal ion binding
Biological Process
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wyo, PDBe:2wyo, PDBj:2wyo
PDBsum2wyo
PubMed20045436
UniProtQ57UN0

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