Structure of PDB 2wyn Chain D

Receptor sequence
>2wynD (length=503) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
TPVTPQPPDILLGPLFNDVQNAKLFPDQKTFADAVPNSDPLMILADYRMQ
QNQSGFDLRHFVNVNFTLPKKYVPPEGQSLREHIDGLWPVLTRSTENTEK
WDSLLPLPEPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKVADMVANFA
HEIDTYGHIPNGNRSYYLSRSQPPFFALMVELLAQHEGDAALKQYLPQMQ
KEYAYWMDGVENLQAGQQEKRVVKLQDGTLLNRYWDDRDTPRPESWVEDI
ATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLNTLRTTSIVPV
DLNSLMFKMEKILARASKAAGDNAMANQYETLANARQKGIEKYLWNDQQG
WYADYDLKSHKVRNQLTAAALFPLYVNAAAKDRANKMATATKTHLLQPGG
LNTTSVKSGQQWDAPNGWAPLQWVATEGLQNYGQKEVAMDISWHFLTNVQ
HTYDREKKLVEKYDVSTTYPLQDGFGWTNGVTLKMLDLICPKEQPCDNVP
ATR
3D structure
PDB2wyn Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.
ChainD
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.28: alpha,alpha-trehalase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LG9 D F153 W159 D160 G310 D312 W447 Y512 F518 W520 F118 W124 D125 G275 D277 W412 Y469 F475 W477
BS02 GLC D Y157 N196 Y202 R205 R277 E279 Y122 N161 Y167 R170 R242 E244
Gene Ontology
Molecular Function
GO:0004555 alpha,alpha-trehalase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process
GO:0006974 DNA damage response
GO:0071474 cellular hyperosmotic response
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wyn, PDBe:2wyn, PDBj:2wyn
PDBsum2wyn
PubMed20461849
UniProtP13482|TREA_ECOLI Periplasmic trehalase (Gene Name=treA)

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