Structure of PDB 2wvj Chain D

Receptor sequence
>2wvjD (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
RGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSALPAC
LLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQ
RKPFGAILNLVPLAESVVKLTAVCMECFREAAYSKRLGTEKEVEVIGGAD
KYHSVCRLCYFK
3D structure
PDB2wvj Comparative Active-Site Mutation Study of Human and Caenorhabditis Elegans Thymidine Kinase 1.
ChainD
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTP D M28 F29 S30 G31 K32 S33 D58 F101 L124 T127 F128 F133 V172 E173 V174 I175 G176 Y181 M11 F12 S13 G14 K15 S16 D41 F72 L95 T98 F99 F104 V143 E144 V145 I146 G147 Y152
BS02 ZN D C153 C156 C185 C188 C124 C127 C156 C159
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2wvj, PDBe:2wvj, PDBj:2wvj
PDBsum2wvj
PubMed22385435
UniProtP04183|KITH_HUMAN Thymidine kinase, cytosolic (Gene Name=TK1)

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