Structure of PDB 2vg3 Chain D

Receptor sequence
>2vg3D (length=283) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PQLPPAPDDYPTFPDTSTWPVVFPELPAAPYGGPCRPPQHTSKAAAPRIP
ADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIACGAIELGIK
WLSLYAFSTENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVGSR
PRLWRSVINELAVAEEMTKSNDVITINYCVNYGGRTEITEATREIAREVA
AGRLNPERITESTIARHLQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAE
YIFQDKLWPDYDRRDLWAACEEYASRTRRFGSA
3D structure
PDB2vg3 The structural basis of chain length control in Rv1086.
ChainD
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D76 H93 I187
Catalytic site (residue number reindexed from 1) D63 H80 I174
Enzyme Commision number 2.5.1.86: trans,polycis-decaprenyl diphosphate synthase.
2.5.1.87: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GPP D D76 G77 N78 G79 R80 R89 H93 A119 R127 N139 D63 G64 N65 G66 R67 R76 H80 A106 R114 N126
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004659 prenyltransferase activity
GO:0008834 di-trans,poly-cis-undecaprenyl-diphosphate synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030145 manganese ion binding
GO:0033850 Z-farnesyl diphosphate synthase activity
GO:0045547 dehydrodolichyl diphosphate synthase activity
GO:0046872 metal ion binding
GO:0052923 all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
Biological Process
GO:0016094 polyprenol biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2vg3, PDBe:2vg3, PDBj:2vg3
PDBsum2vg3
PubMed18597781
UniProtP9WFF7|DPDS_MYCTU Decaprenyl diphosphate synthase (Gene Name=uppS)

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