Structure of PDB 2v22 Chain D

Receptor sequence
>2v22D (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL
3D structure
PDB2v22 Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C35 D M210 L214 W217 E224 Q254 I281 T282 D283 T285 M36 L40 W43 E50 Q80 I107 T108 D109 T111
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0044772 mitotic cell cycle phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:2v22, PDBe:2v22, PDBj:2v22
PDBsum2v22
PubMed17051658
UniProtP20248|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

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