Structure of PDB 2uuu Chain D

Receptor sequence
>2uuuD (length=537) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
GAMGSPKEHIDLYQQIKWNGWGDTRKFLHQLKPSGTIAMTTPEVSSVPLP
SLRGFIKKEFVLDETPALQIENIHVDPPKQYPEFVRELKAFFLPDQLKDD
KLARITHTFGKSLRDLIRVRIGQVKNAPDLIVLPHSHEEVERLVQLAHKY
NVVIIPMGGGSNIVGAIEPVSNERFTVSIDMRRMNKVLWVDRREMTACIQ
VGIMGPELEKQLHKQGVSLGHDPDSFEFSTLGGWLATCSSGHQSDKYGDI
EDMAVSFRTVTPTGTLELRAGINYKHIILGSEGTLGIITEAVMKVHAVPQ
AVEYYGFLFPTFAHAVSALQQIRSSEVIPTMIRVYDPEETQLSFAWKPSS
EFTSAMVKKYLHYIRSFDFKNVCLSIIGFEGPKKVVDFHRTSVFDILSKN
AAFGLGSAPGKTWAEKRYDLPYIRDFLLDHNMWVDVAETTVSYANLQTLW
KDAKQTFVKHFKDQGIPAWICAHISHTYTNGVCLYFIFASKQNAQYIEAK
KLMTDIIFKYGGSLGWINVYRSLKETIDPKDICNPRK
3D structure
PDB2uuu The Crucial Step in Ether Phospholipid Biosynthesis: Structural Basis of a Noncanonical Reaction Associated with a Peroxisomal Disorder.
ChainD
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.26: alkylglycerone-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD D P169 G171 G172 G173 S174 N175 A179 I180 P236 D237 S238 S242 T243 G246 W247 A249 T250 S252 S253 E301 G302 I307 P156 G158 G159 G160 S161 N162 A166 I167 P223 D224 S225 S229 T230 G233 W234 A236 T237 S239 S240 E282 G283 I288
BS02 PL3 D L443 W492 L420 W469
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008609 alkylglycerone-phosphate synthase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0043178 alcohol binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
GO:0008611 ether lipid biosynthetic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2uuu, PDBe:2uuu, PDBj:2uuu
PDBsum2uuu
PubMed17562315
UniProtO96759|ADAS_DICDI Alkyldihydroxyacetonephosphate synthase (Gene Name=eapA)

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