Structure of PDB 2uue Chain D

Receptor sequence
>2uueD (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL
3D structure
PDB2uue Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors
ChainD
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D M210 I213 L214 W217 R250 Q254 T282 D283 T285 M36 I39 L40 W43 R76 Q80 T108 D109 T111
BS02 GVC D W217 E220 V221 Q254 I281 T282 W43 E46 V47 Q80 I107 T108
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0044772 mitotic cell cycle phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:2uue, PDBe:2uue, PDBj:2uue
PDBsum2uue
PubMed17051658
UniProtP20248|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

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