Structure of PDB 2rjp Chain D

Receptor sequence
>2rjpD (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSL
VVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQ
DLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNM
LHDNSKPCISLNSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCL
LDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPPCAALWCSGHLNG
HAMCQTKHSPWADGTPCGPAQACMGGRC
3D structure
PDB2rjp Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.82: ADAMTS-4 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H361 H365 H371 H142 H146 H152
BS02 CA D D320 L321 C327 T329 E349 D101 L102 C108 T110 E130
BS03 CA D E221 D304 D311 C423 D426 E7 D85 D92 C199 D202
BS04 CA D E221 D304 D426 E7 D85 D202
BS05 886 D T329 L330 G331 M332 F357 H361 Q362 H365 H371 V390 P393 V394 M395 V398 T110 L111 G112 M113 F138 H142 Q143 H146 H152 V166 P169 V170 M171 V174 BindingDB: IC50=100nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2rjp, PDBe:2rjp, PDBj:2rjp
PDBsum2rjp
PubMed18042673
UniProtO75173|ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (Gene Name=ADAMTS4)

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