Structure of PDB 2qvw Chain D

Receptor sequence
>2qvwD (length=720) Species: 5741 (Giardia intestinalis) [Search protein sequence]
AMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFE
AGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPR
FISNPPQFATLAFLPLLSPTSPLDLRALMVTAQLMCDAKRLSDEYTDYLS
ASLHGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAH
NIHLRAADLPLVAAVRLDDLKDHQIPAPDDLAPKLRFLPPELCLLLPDEF
DLIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGL
RLDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCL
FPDASVGTLVELKMELVRNEALNYLVQTLGLPQLAEFSKTWADMYEEIVG
SIFTGPNGIYGCEEFLAKTLMSPEHSKTACPDAVTKASKRVCMGEAGAHE
FRSLVDYACEQGISVFCSSRVSTMFLERLRDIPAEDMLDWYRLGIQFSHR
SGLSVSVIDIMTHLARGLWLGSPGFYVEQPPTIPVLYIYHRSVQCPVLYG
SLTTGPVASKVLALYEKILAYEGSKHIAAQTVSRSLAVPIPSGTIPFLIR
LLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAE
TNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACG
EEAAGAFVREHVLPQVVADA
3D structure
PDB2qvw An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D D720 E723 D686 E689
BS02 MN D E336 E407 E332 E396
BS03 MN D K400 T401 D404 K389 T390 D393
BS04 MN D H92 I101 H93 I102
BS05 MN D R494 D495 R480 D481
BS06 MN D R695 F696 R661 F662
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing

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Molecular Function
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Biological Process
External links
PDB RCSB:2qvw, PDBe:2qvw, PDBj:2qvw
PDBsum2qvw
PubMed17704568
UniProtA8BQJ3|DCL_GIAIC Endoribonuclease Dicer-like (Gene Name=GL50803_103887)

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