Structure of PDB 2qg4 Chain D

Receptor sequence

>2qg4D (length=461) Species: 9606 (Homo sapiens) [Search protein sequence]

MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTL
PIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGK
GRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKP
NLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE
HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEE
VATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW
QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSS
IYISKYLMDEGAHLHIYDPKVPREQIVVDLSHDDQVSRLVTISKDPYEAC
DGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTI
GFQIETIGKKV

3D structure

PDB

2qg4 Structure and mechanism of human UDP-glucose 6-dehydrogenase.

Chain

Resolution

2.1 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T131 E165 K220 N224 C276 D280
Catalytic site (residue number reindexed from 1)	T131 E165 K220 N224 C276 D280
Enzyme Commision number	1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	D	I10 G11 G13 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 E161 L163 E165 C276 R346	I10 G11 G13 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 E161 L163 E165 C276 R346
BS02	UGA	D	F162 L163 A164 E165 K220 N224 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442	F162 L163 A164 E165 K220 N224 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R437

Gene Ontology

	Molecular Function
GO:0003979	UDP-glucose 6-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

	Biological Process
GO:0001702	gastrulation with mouth forming second
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006065	UDP-glucuronate biosynthetic process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0034214	protein hexamerization
GO:0048666	neuron development

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2qg4, PDBe:2qg4, PDBj:2qg4
PDBsum	2qg4
PubMed	21502315
UniProt	O60701\|UGDH_HUMAN UDP-glucose 6-dehydrogenase (Gene Name=UGDH)

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