Structure of PDB 2q6c Chain D

Receptor sequence
>2q6cD (length=413) Species: 9606 (Homo sapiens) [Search protein sequence]
PRPNEECLQGAKFLSDAEIIQLVNAKHIPAYKLETLIETHERGVSIRRQL
LSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDE
KEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPR
ACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQ
SRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINW
IEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGG
YNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMP
SIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMA
GELSLMAALAAGH
3D structure
PDB2q6c Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
ChainD
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E559 K691 D767
Catalytic site (residue number reindexed from 1) E111 K243 D319
Enzyme Commision number 1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HR1 D E559 K735 A751 L853 L857 H861 E111 K287 A303 L405 L409 H413 MOAD: ic50=16.7nM
BS02 HR1 D R590 V683 S684 D690 K692 R142 V235 S236 D242 K244 MOAD: ic50=16.7nM
Gene Ontology
Molecular Function
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane

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Cellular Component
External links
PDB RCSB:2q6c, PDBe:2q6c, PDBj:2q6c
PDBsum2q6c
PubMed17574411
UniProtP04035|HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Gene Name=HMGCR)

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