Structure of PDB 2p9e Chain D

Receptor sequence
>2p9eD (length=403) Species: 562 (Escherichia coli) [Search protein sequence]
KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFI
GLRSRTHLTEDVINAAEKLVAIGAFAIGTNQVDLDAAAKRGIPVFNAPFS
NTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGII
GYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVV
SLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALADALASKH
LAGAAIDVFPTEPATNSDPFTSPLAEFDNVLLTPHIGGSTQEAQENIGLE
VAGKLIKYSDNGSTLSAVNFPEVSLPLHVGRRLMHIHENRPGVLTALNKI
FAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRAR
LLY
3D structure
PDB2p9e The Effect of Hinge Mutations on Effector Binding and Domain Rotation in Escherichia coli D-3-Phosphoglycerate Dehydrogenase
ChainD
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N108 R240 D264 E269 H292
Catalytic site (residue number reindexed from 1) N101 R233 D257 E262 H285
Enzyme Commision number 1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI D V112 G160 H161 I162 Y180 D181 I182 K185 H210 V211 P212 A238 S239 R240 H292 G294 G295 V105 G153 H154 I155 Y173 D174 I175 K178 H203 V204 P205 A231 S232 R233 H285 G287 G288
Gene Ontology
Molecular Function
GO:0004617 phosphoglycerate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0047545 2-hydroxyglutarate dehydrogenase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding
GO:0070404 NADH binding
GO:0070905 serine binding
Biological Process
GO:0006564 L-serine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2p9e, PDBe:2p9e, PDBj:2p9e
PDBsum2p9e
PubMed17459882
UniProtP0A9T0|SERA_ECOLI D-3-phosphoglycerate dehydrogenase (Gene Name=serA)

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