Structure of PDB 2oid Chain D

Receptor sequence
>2oidD (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPISVGGNKMGEGFGVVYKGYVNNTTVAVKK
LDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDG
TPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISD
FGLARASEQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIIT
GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSV
ASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB2oid Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
ChainD
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1) D132 K134 A136 N137 D150 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP D G193 E194 G195 F197 V200 A211 K213 M265 K313 N316 L318 D329 G30 E31 G32 F33 V36 A47 K49 M86 K134 N137 L139 D150
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:2oid, PDBe:2oid, PDBj:2oid
PDBsum2oid
PubMed17312103
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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