Structure of PDB 2jgv Chain D

Receptor sequence

>2jgvD (length=310) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325)

HMILTLTLNPSVDISYPLTALKLDDVNRVQEVSKTAGGKGLNVTRVLAQV
GEPVLASGFIGGELGQFIAKKLDHADIKHAFYNIKGETRNCIAILHEGQQ
TEILEQGPEIDNQEAAGFIKHFEQLLEKVEAVAISGSLPKGLNQDYYAQI
IERCQNKGVPVILDCSGATLQTVLENPYKPTVIKPNISELYQLLNQPLDE
SLESLKQAVSQPLFEGIEWIIVSLGAQGAFAKHNHTFYRVNIPTISVLNP
VGSGDSTVAGITSAILNHENDHDLLKKANTLGMLNAQEAQTGYVNLNNYD
DLFNQIEVLV

3D structure

• PDB: 2jgv Structures of Staphylococcus Aureus D-Tagatose-6-Phosphate Kinase Implicate Domain Motions in Specificity and Mechanism.
• Chain: D
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): G251 S252 G253 D254
• Catalytic site (residue number reindexed from 1): G252 S253 G254 D255
• Enzyme Commision number: 2.7.1.144: tagatose-6-phosphate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	D	G224 I244 V246 S252 G253 T256 N278 G281 M282	G225 I245 V247 S253 G254 T257 N279 G282 M283

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0008443 phosphofructokinase activity
• GO:0009024 tagatose-6-phosphate kinase activity
• GO:0016301 kinase activity
• GO:0016772 transferase activity, transferring phosphorus-containing groups
• GO:0016773 phosphotransferase activity, alcohol group as acceptor

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0005988 lactose metabolic process
• GO:0016310 phosphorylation
• GO:0019512 lactose catabolic process via tagatose-6-phosphate
• GO:0046835 carbohydrate phosphorylation
• GO:2001059 D-tagatose 6-phosphate catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:2jgv, PDBe:2jgv, PDBj:2jgv
• PDBsum: 2jgv
• PubMed: 17459874
• UniProt: P0A0B9|LACC_STAA8 Tagatose-6-phosphate kinase (Gene Name=lacC)